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Image Search Results
Journal: Journal of cellular and molecular medicine
Article Title: The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
doi: 10.1111/jcmm.70616
Figure Lengend Snippet: FIGURE 3 | AEP enhances the level of epithelial mesenchymal transition in breast cancer cells by regulating CD74. (A) Expression of related pathway protein after administration of BIC-113 to MCF-7 cells; (B) Protein expression of related pathways after administration of BIC-113 to MDA- MB-231 cells; (C) Protein expression of related pathways in MCF-7 AEP OE cell line and MCF-7 WT cell line; (D) Protein expression of related path- ways after administration of siCD74 to MCF-7 WT cells and MCF-7 shAEP cells.
Article Snippet: HEK293T (RRID:CVCL_0063),
Techniques: Expressing
Journal: Journal of cellular and molecular medicine
Article Title: The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
doi: 10.1111/jcmm.70616
Figure Lengend Snippet: FIGURE 2 | AEP enhances the migration ability of breast cancer cells by regulating CD74. (A) Scratching experiments on different groups of 4 T1.2 cells after administration of siCD74; scale bar is 100 μm; (B) Statistics of the results of scratching experiments on different groups of 4 T1.2 cells; (C) Transwell migration experiments on different groups of 4 T1.2 cells after administration of siCD74; scale bar is 100 μm; (D) Statistics of the results of transwell migration experiments on different groups of 4 T1.2 cells. Compared with the control group, *p < 0.05, **p < 0.01.
Article Snippet: HEK293T (RRID:CVCL_0063),
Techniques: Migration, Control
Journal: Journal of cellular and molecular medicine
Article Title: The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
doi: 10.1111/jcmm.70616
Figure Lengend Snippet: FIGURE 4 | Exogenous AEP enhances the level of epithelial mesen- chymal transition in breast cancer cells. (A) Cell co-culture model; (B) Protein expression of 293 T WT and 293 T shAEP cells; (C) AEP levels in the supernatant of 293 T WT and 293 T shAEP cells; (D) Expression of MCF-7 cell-associated proteins after co-culture with different groups of 293 T cells. Compared with the control group. *p < 0.05.
Article Snippet: HEK293T (RRID:CVCL_0063),
Techniques: Co-Culture Assay, Expressing, Control
Journal: Journal of cellular and molecular medicine
Article Title: The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
doi: 10.1111/jcmm.70616
Figure Lengend Snippet: FIGURE 5 | Combined inhibition of AEP and CD74 can reduce the migration ability of breast cancer cells and the level of epithelial mesenchymal transformation. (A) Cell viability of MCF-7 cell line with different dosing regimens; (B) Results of wound healing assay of MCF-7 cell line, scale bar is 100 μM; (C) Results of transwell migration assay of MCF-7 cell line, scale bar is 100 μM; (D, E) Statistics of wound healing assay or transwell migra- tion assay of MCF-7 cell line; Compared with the control group. *p < 0.05, **p < 0.01, ns p > 0.05; (F) Combined inhibition of AEP and CD74 reduces the level of epithelial mesenchymal transition in breast cancer cells.
Article Snippet: HEK293T (RRID:CVCL_0063),
Techniques: Inhibition, Migration, Transformation Assay, Wound Healing Assay, Transwell Migration Assay, Control
Journal: Journal of cellular and molecular medicine
Article Title: The Combination of MIF Inhibitor and AEP Targeted Inhibitor to Reduce Lung Metastasis in Breast Cancer and Its Mechanism.
doi: 10.1111/jcmm.70616
Figure Lengend Snippet: FIGURE 6 | Combined inhibition of AEP and CD74 to overcome breast cancer lung metastasis. (A) Experimental protocol for breast cancer lung metastasis animals; (B) Body weight statistics of mice in each group; (C) Photographs of lung metastases in each group of mice, with red arrows indicating lung metastases; (D) The number of lung metastases in each group of mice; (E) HE staining of lung tissues in each group of mice; (F), Immunohistochemistry of AEP, CD74 and E-cadherin in lung tissues of mice in each group. Compared with the control group: *p < 0.05, **p < 0.01.
Article Snippet: HEK293T (RRID:CVCL_0063),
Techniques: Inhibition, Staining, Immunohistochemistry, Control